Crizotinib

Catalog Number	ACM877399525
CAS	877399-52-5
Structure
IUPAC Name	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Synonyms	Crizotinib;877399-52-5;Xalkori;PF-02341066;(R)-crizotinib;PF-2341066;PF 2341066;Crizotinib (PF-02341066);3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine;PF 02341066;(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;UNII-53AH36668S;PF2341066;CHEMBL601719;Crizotinib (PF-2341066);CHEBI:64310;877399-52-5 (free base);53AH36668S;3-[(1R)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-[1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YL]PYRIDIN-2-AMINE;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine;3-[(1r)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-Yl-1h-Pyrazol-4-Yl)pyridin-2-Amine;(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine;Xalkori (TN);C21H22Cl2FN5O;Crizotinib [USAN:INN];crizotinibum;VGH;PubChem19322;PF02341066;SCHEMBL93829;PF-2341066,Crizotinib;cc-190;Crizotinib (JAN/USAN/INN);PF-2341066(Crizotinib);GTPL4903;QCR-32;Crizotinib, >=98% (HPLC);PF-2341066 (Crizotinib);PF-2341066 - Crizotinib;AOB2688;EX-A096;SYN1139;PF-02341066 (Crizotinib);BCPP000116;DTXSID701009329;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;AMY10313;ABP000131;ANW-47749;BDBM50306682;MFCD12407409;NSC749005;NSC749769;NSC800080;ZINC35902489;AKOS015901233;AKOS015995207;CCG-264803;DB08865;GS-6178;NSC-749005;NSC-749769;NSC-800080;PB11015;NCGC00250400-01;NCGC00250400-02;NCGC00250400-09;NCGC00250400-12;2-Pyridinamine, 3-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(4-piperidinyl)-1H-pyrazol-4-yl)-;HY-50878;AB0027203;BB 0261738;SW202555-3;W9013;D09731;Q-3209;399P525;J-510370;Q5186964;BRD-K78431006-001-01-1;BRD-K78431006-001-03-7;877399-52-5, 877399-53-6 (acetate);3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-am ine;3-(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy-5-1-(4-piperidinyl)-1H-pyrazol-4-yl-2-Pyridinamine;3-[(R)-1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
Molecular Weight	450.3g/mol
Molecular Formula	C21H22Cl2FN5O
Canonical SMILES	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChI	InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChI Key	KTEIFNKAUNYNJU-GFCCVEGCSA-N
Complexity	558
Covalently-Bonded Unit Count	1
Exact Mass	449.1185439g/mol
Heavy Atom Count	30
Hydrogen Bond Acceptor Count	6
Monoisotopic Mass	449.1185439g/mol
NSC Number	749005
Rotatable Bond Count	5
Topological Polar Surface Area	78Å²
UNII	53AH36668S
X Log P3	3.7

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